WDR7-OT1

Across TCGA pan-cancer cohorts, WDR7-OT1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of WDR7-OT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WDR7-OT1 RNA is repressed in tumor relative to normal tissue. In most cancer types WDR7-OT1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, LUSC, and BRCA are the cancer types where WDR7-OT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR7-OT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.063	<.001	7	view →
LUSC	All	All	+0.035	.009	2	view →
BRCA	All	III,IV	+0.029	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

WDR7-OT1–THCA

Open the THCA breakdown →