WDR64

Across TCGA patient cohorts, WDR64 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR64-associated genes across cancer lineages are LKB1, MEK1, and HER2. Each is linked with WDR64 in more than 3 cancer types. Because this analysis shows association rather than direction, both WDR64-to-partner and partner-to-WDR64 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by WDR64-low versus WDR64-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR64→partner) and Y-score (partner→WDR64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LKB1 →	+0.163	+2.215	.021	.032	3	3
UCEC	MEK1 →	+0.420	+2.700	<.001	<.001	3	3
UCEC	HER2 →	+0.321	+2.459	.029	.018	3	3
UCEC	p62 Lck ligand →	+0.411	+2.000	<.001	<.001	3	3
LUAD	PR →	-0.210	-3.136	.005	.019	1	4
SKCM	eIF4G →	+0.438	+3.000	.026	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

LKB1 by WDR64 expression — LUSC

Explore this box plot interactively →