WDR61

Across TCGA pan-cancer cohorts, WDR61 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated WDR61 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher WDR61 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDR61 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where WDR61 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.511	0.979	.018	10	view →
PDAC	DFS	Median	II,III,IV	0.463	0.320	.025	9	view →
HNSC	OS	Tertile	All	0.926	1.000	.013	9	view →
UCEC	DFS	Median	All	0.940	0.780	.010	8	view →
OV	DFS	Median	All	0.894	0.701	.049	4	view →
CCRCC	DFS	Quartile	All	0.887	1.000	.033	3	view →
LUAD	OS	Median	All	0.999	0.931	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

WDR61–LSCC (DFS)

Open the LSCC breakdown →