WDR61

Across TCGA pan-cancer cohorts, WDR61 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WDR61’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WDR61 RNA is repressed in tumor relative to normal tissue. In most cancer types WDR61 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where WDR61 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR61 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−0.745	<.001	10	view →
LIHC	Male	III,IV	+0.860	<.001	8	view →
KICH	Female	All	−0.918	<.001	7	view →
COAD	Female	II,III,IV	+0.674	<.001	6	view →
KIRP	Male	All	−0.419	<.001	6	view →
CHOL	All	All	+1.414	<.001	5	view →
HNSC	Male	IV	+0.521	<.001	4	view →
BRCA	All	III,IV	+0.303	.015	4	view →
BLCA	All	III,IV	+0.291	.023	4	view →
KIRC	Male	II,III,IV	−0.252	.008	4	view →
LUAD	Female	II,III,IV	−0.304	.019	2	view →
LUSC	All	All	+0.231	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WDR61–THCA

Open the THCA breakdown →