WDR59

Across TCGA pan-cancer cohorts, WDR59 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated WDR59 data layer compared with 19 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher WDR59 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDR59 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

READ, STAD, and SCLC are the cancer types where WDR59 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.059	0.845	<.001	36	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
SCLC	DFS	Median	II,III,IV	1.000	0.298	.022	10	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	6	view →
HNSC	OS	Median	II,III,IV	0.182	0.601	.029	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.943	0.630	.027	4	view →
ACC	DFS	Median	All	0.112	0.544	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

WDR59–READ (DFS)

Open the READ breakdown →