WDR59

Across TCGA pan-cancer cohorts, WDR59 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WDR59 data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WDR59 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR59 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where WDR59 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.976	0.856	.008	18	view →
LSCC	DFS	Tertile	All	0.338	1.000	.004	10	view →
HNSC	OS	Quartile	III,IV	1.000	0.896	.035	8	view →
PDAC	DFS	Quartile	II,III,IV	0.226	0.422	.033	2	view →
LUAD	DFS	Median	All	0.823	0.537	.035	2	view →
GBM	OS	Median	All	0.418	0.621	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WDR59–CCRCC (DFS)

Open the CCRCC breakdown →