WDR55

Across TCGA pan-cancer cohorts, WDR55 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WDR55 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WDR55 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDR55 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where WDR55 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.346	0.725	.008	6	view →
UCEC	OS	Median	II,III,IV	1.000	0.666	.025	4	view →
LSCC	OS	Median	All	0.793	1.000	.025	4	view →
PDAC	OS	Tertile	III,IV	0.225	0.652	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WDR55–CCRCC (DFS)

Open the CCRCC breakdown →