WDR55

Across TCGA patient cohorts, WDR55 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR55-associated genes across cancer lineages are MEK1, ASNS, and PDCD4. Each is linked with WDR55 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR55-to-partner and partner-to-WDR55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by WDR55-low versus WDR55-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR55→partner) and Y-score (partner→WDR55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.421	+3.321	.028	.010	3	1
UCEC	ASNS →	+0.690	+2.999	<.001	.035	3	1
UCEC	PDCD4 →	-0.684	-3.321	.005	.010	2	1
UCEC	Cyclin-B1 →	+0.918	+3.321	.001	.010	2	1
UCEC	p62 Lck ligand →	+0.434	+3.321	.010	.010	1	1
UCEC	4E-BP1 →	+0.321	+3.321	.023	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1 by WDR55 expression — UCEC

Explore this box plot interactively →