WDR55

Across TCGA cell cohorts, WDR55 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR55-associated genes across cancer lineages are C1QL2, TSPY8, and MDGA2. Each is linked with WDR55 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR55-to-partner and partner-to-WDR55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QL2 grouped by WDR55-low versus WDR55-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR55→partner) and Y-score (partner→WDR55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1QL2 →	+0.012	+4.922	<.001	.009	3	2
OVARY	TSPY8 →	+0.031	+5.196	<.001	.005	3	1
LARGE_INTESTINE	MDGA2 →	+0.193	+4.176	<.001	.001	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1
LARGE_INTESTINE	LRRC3C →	+0.351	+3.658	<.001	.005	3	1
LARGE_INTESTINE	LIPK →	+0.235	+3.554	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C1QL2 by WDR55 expression — BLOOD_Leukemia

Explore this box plot interactively →