Across TCGA patient cohorts, WDR5 mutation is significantly associated with the RNA expression of many other genes, with 607 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR5-associated genes across cancer lineages are RNA5SP442, RN7SKP172, and RNA5SP54. Each is linked with WDR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR5-to-partner and partner-to-WDR5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR5→partner) and Y-score (partner→WDR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP442 →	+0.245	+1.936	.007	.009	3	2
UCEC	RN7SKP172 →	+0.065	+2.381	.008	.009	3	2
UCEC	RNA5SP54 →	+0.141	+2.919	.001	.007	3	2
UCEC	RNU6-218P →	+0.529	+2.245	<.001	<.001	3	2
BRCA	MIR4307 →	+0.245	+7.731	<.001	.009	3	1
BRCA	MIR3169 →	+0.253	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 607 associations by consensus.

Exploration

WDR5 survival (RNA) · tumor vs normal (RNA) · all WDR5 data types