WDR49

Across TCGA cell cohorts, WDR49 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR49-associated genes across cancer lineages are CBLL2, GZMA, and CLRN1. Each is linked with WDR49 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR49-to-partner and partner-to-WDR49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLL2 grouped by WDR49-low versus WDR49-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR49→partner) and Y-score (partner→WDR49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CBLL2 →	+0.041	+4.523	<.001	.003	3	2
LUNG_NSCLC_LUAD	GZMA →	+0.446	+2.958	.001	.004	3	1
LUNG_NSCLC_LUAD	CLRN1 →	+0.012	+3.681	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10A4 →	+0.043	+4.617	<.001	<.001	3	1
LUNG_NSCLC_LUAD	HSFY1 →	+0.008	+3.491	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP6-1 →	+0.027	+3.681	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

CBLL2 by WDR49 expression — LUNG_SCLC

Explore this box plot interactively →