WDR48

Across TCGA patient cohorts, WDR48 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR48-associated genes across cancer lineages are ATM, c-Met_pY1235, and VHL. Each is linked with WDR48 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR48-to-partner and partner-to-WDR48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by WDR48-low versus WDR48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR48→partner) and Y-score (partner→WDR48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.600	-2.169	<.001	.003	3	3
UCEC	c-Met_pY1235 →	+0.068	+2.009	.014	.005	3	3
UCEC	VHL →	-0.998	-2.415	<.001	.003	3	2
UCEC	FASN →	+0.313	+1.415	.034	.046	3	1
UCEC	FoxM1 →	+0.223	+1.765	.021	.014	3	1
UCEC	ACC_pS79 →	+0.289	+2.331	.026	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by WDR48 expression — UCEC

Explore this box plot interactively →