WDR46

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, WDR46 mutation is significantly associated with the RNA expression of many other genes, with 4,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR46-associated genes across cancer lineages are RNA5SP113, DEFB130D, and CRLF3P2. Each is linked with WDR46 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR46-to-partner and partner-to-WDR46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR46→partner) and Y-score (partner→WDR46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
KIRCRNA5SP113 →+0.663+5.985<.001.00232
HNSCDEFB130D →+0.450+6.339<.001.00132
HNSCCRLF3P2 →+0.055+5.069<.001.00832
UCECZNF280B →+0.552+2.534<.001<.00132
UCECMAP6D1 →+0.473+3.169.002<.00132
UCECUQCR10 →+0.338+2.917.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,095 associations by consensus.

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