Q-omics provides the consensus-scored DEFB130D profile across patient tissues and cancer cell-line models. DEFB130D expression is associated with patient survival in 6 of 34 cancer types, with the highest sampling consensus in READ. Additionally, DEFB130D RNA expression shows 12,028 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight READ, and COAD as cancer lineages where DEFB130D shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Premium analyses for DEFB130D — synthetic lethality, tumor antigen, and pembrolizumab response.

View premium →

Survival associations

This table summarizes DEFB130D survival associations across molecular data types. DEFB130D RNA expression shows survival associations in the most cancer types (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DEFB130D data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	6	READ (72)	view →

This table ranks reproducible DEFB130D RNA expression–survival associations across cancer types. High DEFB130D expression shows unfavorable associations in READ, PAAD, KIRC, STAD, THYM and KIRP. The READ Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify READ as the clearest survival context for DEFB130D RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	II,III,IV	0.054	0.934	<.001	72	view →
PAAD	DFS	Tertile	II,III,IV	0.136	0.442	<.001	54	view →
KIRC	OS	Tertile	All	0.409	0.678	<.001	36	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
THYM	OS	Tertile	All	0.470	0.975	.003	9	view →
KIRP	OS	Tertile	All	0.761	0.951	.009	6	view →

Pink = unfavorable, green = favorable. all 6 lineages →

DEFB130D-READ (OS)

Kaplan–Meier survival curve for DEFB130D RNA expression in READ: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with DEFB130D in patient tissues and cancer cell lines. In patient samples, DEFB130D shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	12,028	COAD (4315)	view →
Function (RNA)	6,414	STAD (6024)	view →