WDR45B

Across TCGA pan-cancer cohorts, WDR45B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR45B data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WDR45B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR45B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where WDR45B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	1.000	0.321	.008	32	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	11	view →
PDAC	DFS	Quartile	All	0.582	0.757	.008	10	view →
LUAD	OS	Quartile	All	0.650	1.000	.033	2	view →
GBM	DFS	Tertile	All	0.555	0.831	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR45B–UCEC (DFS)

Open the UCEC breakdown →