WDR45B

Across TCGA pan-cancer cohorts, WDR45B RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of WDR45B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where WDR45B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR45B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, COAD, and THCA are the cancer types where WDR45B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR45B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+0.838	<.001	11	view →
COAD	Male	All	+0.725	<.001	10	view →
THCA	Male	III,IV	−0.458	<.001	10	view →
LIHC	All	III,IV	+1.066	<.001	9	view →
LUAD	Male	All	+0.665	<.001	9	view →
UCEC	All	All	+0.576	.023	6	view →
KICH	Female	II,III,IV	−1.057	<.001	5	view →
LUSC	Female	All	+0.942	<.001	5	view →
KIRP	All	IV	+0.719	.007	5	view →
STAD	All	All	+0.591	<.001	4	view →
BRCA	All	II,III,IV	+0.217	.012	4	view →
CHOL	Male	All	+2.110	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

WDR45B–BLCA

Open the BLCA breakdown →