WDR45B

Across TCGA patient cohorts, WDR45B mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR45B-associated genes across cancer lineages are ATM, EGFR_pY1068, and A-Raf_pS299. Each is linked with WDR45B in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR45B-to-partner and partner-to-WDR45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by WDR45B-low versus WDR45B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR45B→partner) and Y-score (partner→WDR45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.504	-2.308	.008	.033	3	2
UCEC	EGFR_pY1068 →	-0.302	-2.222	.004	.011	3	1
UCEC	A-Raf_pS299 →	-0.164	-2.000	.001	.030	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-3.575	.007	.002	3	1
UCEC	ACC1 →	+0.376	+3.013	.014	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-1.687	.013	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by WDR45B expression — UCEC

Explore this box plot interactively →