WDR36

Across TCGA pan-cancer cohorts, WDR36 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated WDR36 data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher WDR36 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR36 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, UCEC, and STAD are the cancer types where WDR36 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	III,IV	0.889	0.422	.007	25	view →
UCEC	OS	Median	All	0.973	0.646	.008	14	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
UCS	OS	Median	All	0.153	0.687	.019	6	view →
SARC	OS	Median	All	0.238	0.826	.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.226	0.769	.008	3	view →
CESC	DFS	Median	All	1.000	0.523	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

WDR36–BLCA (DFS)

Open the BLCA breakdown →