WDR36

Across TCGA patient cohorts, WDR36 mutation is significantly associated with the RNA expression of many other genes, with 3,356 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR36-associated genes across cancer lineages are L2HGDH, SLC7A11, and SAR1B. Each is linked with WDR36 in more than 3 cancer types. Because this analysis shows association rather than direction, both WDR36-to-partner and partner-to-WDR36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L2HGDH grouped by WDR36-low versus WDR36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR36→partner) and Y-score (partner→WDR36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	L2HGDH →	+0.426	+2.539	<.001	<.001	3	4
UCEC	SLC7A11 →	+0.803	+2.146	<.001	<.001	3	3
UCEC	SAR1B →	+0.376	+1.962	<.001	<.001	3	3
UCEC	BUB3 →	+0.477	+2.075	<.001	<.001	3	3
UCEC	PCBD1 →	+0.399	+2.180	<.001	.001	3	3
UCEC	CDKN3 →	+0.741	+2.157	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,356 associations by consensus.

L2HGDH by WDR36 expression — UCEC

Explore this box plot interactively →