WDR36

Across TCGA patient cohorts, WDR36 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR36-associated genes across cancer lineages are MEK1, FASN, and Notch1. Each is linked with WDR36 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR36-to-partner and partner-to-WDR36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by WDR36-low versus WDR36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR36→partner) and Y-score (partner→WDR36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.339	+2.169	.003	.003	3	3
UCEC	FASN →	+0.367	+2.700	.003	.005	3	2
UCEC	Notch1 →	+0.179	+1.836	<.001	.001	3	2
UCEC	S6_pS240_S244 →	+0.333	+2.222	.009	.010	3	2
UCEC	Shc_pY317 →	-0.130	-1.502	.006	.027	3	2
UCEC	ASNS →	+0.379	+1.765	<.001	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by WDR36 expression — UCEC

Explore this box plot interactively →