WDR35

Across TCGA patient cohorts, WDR35 mutation is significantly associated with the RNA expression of many other genes, with 3,478 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR35-associated genes across cancer lineages are CIDECP1, DHRS13, and PXMP2. Each is linked with WDR35 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR35-to-partner and partner-to-WDR35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CIDECP1 grouped by WDR35-low versus WDR35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR35→partner) and Y-score (partner→WDR35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CIDECP1 →	+0.538	+2.486	<.001	<.001	3	3
UCEC	DHRS13 →	+0.555	+2.280	.002	<.001	3	3
UCEC	PXMP2 →	+0.562	+2.264	<.001	.001	3	3
UCEC	WDR18 →	+0.507	+2.443	<.001	<.001	3	3
UCEC	TIMM21 →	+0.447	+2.126	<.001	<.001	3	3
UCEC	C14orf119 →	+0.240	+1.857	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,478 associations by consensus.

CIDECP1 by WDR35 expression — UCEC

Explore this box plot interactively →