WDR35

Across TCGA cell cohorts, WDR35 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible WDR35-associated genes across cancer lineages are TSHB, OR1L3, and OR4E1. Each is linked with WDR35 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR35-to-partner and partner-to-WDR35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by WDR35-low versus WDR35-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR35→partner) and Y-score (partner→WDR35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TSHB →	+0.058	+3.832	<.001	.005	3	1
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	1
BREAST	OR4E1 →	+0.150	+5.781	<.001	.001	3	1
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TSHB by WDR35 expression — CNS

Explore this box plot interactively →