WDR11

Across TCGA pan-cancer cohorts, WDR11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR11 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher WDR11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR11 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

GBM, CCRCC, and LUAD are the cancer types where WDR11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.270	0.533	.006	9	view →
CCRCC	OS	Tertile	IV	0.199	1.000	.036	6	view →
LUAD	OS	Median	II,III,IV	0.460	0.758	.014	4	view →
PDAC	OS	Median	II,III,IV	0.287	0.491	.036	4	view →
LSCC	DFS	Tertile	II,III,IV	0.955	0.889	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR11–GBM (OS)

Open the GBM breakdown →