WDR11

Across TCGA pan-cancer cohorts, WDR11 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of WDR11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where WDR11 RNA is repressed in tumor relative to normal tissue. In most cancer types WDR11 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where WDR11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.018	<.001	8	view →
THCA	All	II,III,IV	−0.501	<.001	8	view →
LIHC	Female	All	+0.639	<.001	7	view →
CHOL	All	All	+1.166	<.001	5	view →
STAD	Male	II,III,IV	+0.715	.007	4	view →
BRCA	Female	All	−0.243	<.001	4	view →
HNSC	All	III,IV	+0.418	.033	3	view →
KIRC	Male	II,III,IV	−0.326	.024	3	view →
UCEC	All	IV	−1.370	.029	2	view →
COAD	Male	All	+0.207	.027	2	view →
ESCA	Female	All	+0.703	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

WDR11–KICH

Open the KICH breakdown →