WDR11

Across TCGA patient cohorts, WDR11 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR11-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and eIF4E. Each is linked with WDR11 in more than 4 cancer types. Because this analysis shows association rather than direction, both WDR11-to-partner and partner-to-WDR11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by WDR11-low versus WDR11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR11→partner) and Y-score (partner→WDR11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.980	+2.593	.003	.006	3	5
UCEC	ATM →	-0.467	-1.893	<.001	<.001	3	3
BLCA	eIF4E →	+0.157	+3.187	.044	.010	1	4
COAD	EGFR_pY1068 →	-0.369	-3.000	.007	.034	3	2
UCEC	Fibronectin →	-0.225	-1.405	.027	.043	3	2
COAD	INPP4B →	-0.495	-3.321	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by WDR11 expression — COAD

Explore this box plot interactively →