WDR1

Across TCGA pan-cancer cohorts, WDR1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WDR1 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher WDR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

GBM, PDAC, and LSCC are the cancer types where WDR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.204	0.445	<.001	23	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
LSCC	DFS	Quartile	III,IV	0.531	1.000	.013	12	view →
HNSC	DFS	Quartile	III,IV	0.902	0.628	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WDR1–GBM (DFS)

Open the GBM breakdown →