WDR1

Across TCGA pan-cancer cohorts, WDR1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WDR1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where WDR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR1 is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

LIHC, HNSC, and BLCA are the cancer types where WDR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.209	<.001	9	view →
HNSC	All	All	+0.373	.001	7	view →
BLCA	All	All	−0.495	.001	6	view →
KIRC	Male	II,III,IV	−0.452	<.001	6	view →
BRCA	All	II,III,IV	+0.358	<.001	6	view →
CHOL	Male	All	+1.988	<.001	5	view →
COAD	Male	All	−0.396	<.001	4	view →
UCEC	All	All	−0.550	.015	2	view →
PRAD	All	All	−0.496	<.001	2	view →
STAD	All	II,III,IV	+0.424	.022	2	view →
READ	All	All	−0.532	.020	1	view →
KIRP	Male	All	−0.292	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WDR1–LIHC

Open the LIHC breakdown →