WDR1

Across TCGA cell cohorts, WDR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,846 significant associations in total. BONE shows the largest number of these associations.

The most reproducible WDR1-associated GO terms across cancer lineages are Positive regulation of aggrephagy, Endocytic recycling, and Regulation of cell-substrate junction organization. Each is linked with WDR1 in more than 13 cancer types. Because this analysis shows association rather than direction, both WDR1-to-partner and partner-to-WDR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of aggrephagy grouped by WDR1-low versus WDR1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR1→partner) and Y-score (partner→WDR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of aggrephagy →	+0.168	+1.058	<.001	<.001	3	14
BONE	Endocytic recycling →	+0.077	+1.586	.002	<.001	3	14
BONE	Regulation of cell-substrate junction organization →	+0.151	+1.500	<.001	<.001	3	13
BREAST	Endosomal transport →	+0.061	+1.413	<.001	<.001	3	13
PANCREAS	Regulation of aggrephagy →	+0.128	+0.763	<.001	.001	3	12
CNS	Regulation of early endosome to late endosome transport →	+0.139	+1.475	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,846 associations by consensus.

Positive regulation of aggrephagy by WDR1 expression — LARGE_INTESTINE

Explore this box plot interactively →