WDFY4

Across TCGA patient cohorts, WDFY4 mutation is significantly associated with the RNA expression of many other genes, with 4,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDFY4-associated genes across cancer lineages are ZNF136, SRRD, and CERT1. Each is linked with WDFY4 in more than 3 cancer types. Because this analysis shows association rather than direction, both WDFY4-to-partner and partner-to-WDFY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF136 grouped by WDFY4-low versus WDFY4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY4→partner) and Y-score (partner→WDFY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF136 →	+0.246	+1.874	.006	.003	3	4
UCEC	SRRD →	+0.267	+1.157	<.001	<.001	3	4
UCEC	CERT1 →	+0.458	+1.317	<.001	<.001	3	4
UCEC	ATF4 →	+0.273	+1.110	<.001	<.001	3	4
CESC	ZSCAN31 →	+0.795	+3.097	<.001	<.001	3	4
UCEC	RAD17 →	+0.287	+1.157	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,440 associations by consensus.

ZNF136 by WDFY4 expression — COAD

Explore this box plot interactively →