WDFY4

Across TCGA patient cohorts, WDFY4 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDFY4-associated genes across cancer lineages are eEF2, p70-S6K_pT389, and PRAS40_pT246. Each is linked with WDFY4 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDFY4-to-partner and partner-to-WDFY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by WDFY4-low versus WDFY4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY4→partner) and Y-score (partner→WDFY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.258	+1.530	.001	.002	3	3
UCEC	p70-S6K_pT389 →	-0.134	-1.628	.001	<.001	3	3
UCEC	PRAS40_pT246 →	+0.117	+1.000	.002	.017	3	3
UCEC	Chk2_pT68 →	-0.136	-1.973	.001	<.001	3	3
COAD	Bak →	+0.087	+1.168	.015	.019	3	3
UCEC	14-3-3_beta →	-0.100	-2.120	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

eEF2 by WDFY4 expression — UCEC

Explore this box plot interactively →