WDFY3-AS2

Across TCGA pan-cancer cohorts, WDFY3-AS2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of WDFY3-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where WDFY3-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types WDFY3-AS2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRP are the cancer types where WDFY3-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDFY3-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.931	<.001	10	view →
THCA	Male	III,IV	−1.322	<.001	10	view →
KIRP	All	III,IV	−1.147	<.001	9	view →
LUAD	Female	III,IV	−1.124	<.001	9	view →
KIRC	Male	III,IV	−0.993	<.001	9	view →
COAD	All	All	−0.264	<.001	9	view →
LUSC	Male	III,IV	−1.360	<.001	8	view →
BLCA	Male	IV	−1.310	<.001	8	view →
UCEC	All	All	−1.239	<.001	6	view →
BRCA	Female	All	−0.851	<.001	6	view →
HNSC	Male	All	−0.392	<.001	6	view →
CHOL	All	All	+1.020	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

WDFY3-AS2–KICH

Open the KICH breakdown →