WDCP

Across TCGA patient cohorts, WDCP mutation is significantly associated with the RNA expression of many other genes, with 2,889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDCP-associated genes across cancer lineages are MED27, NUP188, and KIF2C. Each is linked with WDCP in more than 2 cancer types. Because this analysis shows association rather than direction, both WDCP-to-partner and partner-to-WDCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED27 grouped by WDCP-low versus WDCP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDCP→partner) and Y-score (partner→WDCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED27 →	+0.330	+2.785	.002	.002	3	3
UCEC	NUP188 →	+0.554	+2.378	<.001	<.001	3	3
UCEC	KIF2C →	+0.592	+1.788	.005	.001	3	3
UCEC	ZNHIT3 →	+0.405	+2.776	<.001	<.001	3	2
LUAD	MIR6885 →	+0.755	+5.044	<.001	.009	3	2
UCEC	UHRF1 →	+0.806	+1.788	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,889 associations by consensus.

MED27 by WDCP expression — UCEC

Explore this box plot interactively →