WDCP

Across TCGA pan-cancer cohorts, WDCP RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated WDCP data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher WDCP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDCP expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LIHC, MESO, and KIRP are the cancer types where WDCP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.457	0.624	<.001	118	view →
MESO	DFS	Tertile	All	0.241	0.497	<.001	95	view →
KIRP	DFS	Tertile	All	0.508	0.779	<.001	85	view →
ACC	DFS	Median	All	0.291	0.642	<.001	80	view →
KICH	DFS	Tertile	II,III,IV	0.503	0.963	.001	54	view →
KIRC	DFS	Quartile	All	0.737	0.430	<.001	42	view →
SKCM	DFS	Tertile	II,III,IV	0.545	0.772	.001	29	view →
READ	OS	Median	IV	0.878	0.502	.007	28	view →
LGG	OS	Quartile	All	0.812	0.932	<.001	24	view →
UCS	DFS	Tertile	IV	0.250	0.814	.024	24	view →
UCEC	DFS	Tertile	All	0.777	0.884	.002	22	view →
OV	DFS	Median	IV	0.397	0.231	.014	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

WDCP–LIHC (DFS)

Open the LIHC breakdown →