WDCP

Across TCGA patient cohorts, WDCP mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDCP-associated genes across cancer lineages are IGFBP2, JNK_pT183_Y185, and PKC-b-II_pS660. Each is linked with WDCP in more than 1 cancer types. Because this analysis shows association rather than direction, both WDCP-to-partner and partner-to-WDCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by WDCP-low versus WDCP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDCP→partner) and Y-score (partner→WDCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.711	-1.874	.002	.049	3	2
UCEC	JNK_pT183_Y185 →	-0.140	-1.807	.023	.025	3	2
UCEC	PKC-b-II_pS660 →	-0.255	-1.502	.012	.030	3	2
UCEC	Rab25 →	-0.359	-1.502	.003	.030	3	2
UCEC	ATM →	-0.507	-1.847	.002	.008	3	2
BLCA	B-Raf →	+0.481	+2.824	.037	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

IGFBP2 by WDCP expression — UCEC

Explore this box plot interactively →