WDCP

Across TCGA cell cohorts, WDCP mutation is significantly associated with the RNA expression of many other genes, with 406 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDCP-associated genes across cancer lineages are IL22, LRRC72, and CBY1. Each is linked with WDCP in more than 1 cancer types. Because this analysis shows association rather than direction, both WDCP-to-partner and partner-to-WDCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by WDCP-low versus WDCP-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDCP→partner) and Y-score (partner→WDCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IL22 →	+0.035	+4.285	<.001	.007	3	1
STOMACH	LRRC72 →	+0.070	+4.285	<.001	.007	3	1
LARGE_INTESTINE	CBY1 →	+0.597	+2.451	.001	.009	3	1
LARGE_INTESTINE	RNMT →	+0.558	+2.537	.005	.008	3	1
LARGE_INTESTINE	CCDC113 →	+1.002	+2.451	<.001	.009	3	1
LARGE_INTESTINE	HOXA2 →	-0.696	-3.169	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 406 associations by consensus.

IL22 by WDCP expression — STOMACH

Explore this box plot interactively →