WBP4

Across TCGA pan-cancer cohorts, WBP4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WBP4 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WBP4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WBP4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, GBM, and HNSC are the cancer types where WBP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.917	0.776	.006	21	view →
GBM	OS	Tertile	All	0.519	0.297	.009	14	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.912	.025	8	view →
LUAD	OS	Tertile	All	0.889	0.512	.028	6	view →
LSCC	DFS	Tertile	II,III,IV	0.858	0.560	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WBP4–PDAC (OS)

Open the PDAC breakdown →