WBP4

Across TCGA pan-cancer cohorts, WBP4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WBP4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WBP4 RNA is repressed in tumor relative to normal tissue. In most cancer types WBP4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where WBP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WBP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.440	<.001	10	view →
KICH	Female	II,III,IV	−1.465	<.001	9	view →
LUAD	Female	III,IV	−0.692	<.001	9	view →
LUSC	All	All	−0.301	<.001	8	view →
BRCA	All	III,IV	−0.726	<.001	6	view →
LIHC	Male	All	+0.473	<.001	6	view →
BLCA	All	All	−0.424	.005	6	view →
CHOL	All	II,III,IV	+1.145	.004	4	view →
HNSC	Female	III,IV	+0.611	.002	4	view →
COAD	Male	All	+0.470	.005	4	view →
KIRP	Male	All	−0.350	.009	4	view →
UCEC	All	All	−0.786	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WBP4–THCA

Open the THCA breakdown →