WBP4

Across TCGA patient cohorts, WBP4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WBP4-associated genes across cancer lineages are EGFR_pY1068, MSH2, and TFRC. Each is linked with WBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WBP4-to-partner and partner-to-WBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by WBP4-low versus WBP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WBP4→partner) and Y-score (partner→WBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.318	-3.169	.001	<.001	3	2
UCEC	MSH2 →	-0.179	-3.143	.048	.018	3	2
UCEC	TFRC →	+0.775	+3.459	<.001	.005	3	2
UCEC	eEF2 →	+0.449	+2.502	.001	.002	3	1
UCEC	GAPDH →	+0.458	+2.000	.029	.010	3	1
UCEC	GATA6 →	-0.167	-1.899	.007	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR_pY1068 by WBP4 expression — UCEC

Explore this box plot interactively →