Across TCGA pan-cancer cohorts, WBP1LP1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of WBP1LP1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WBP1LP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WBP1LP1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
KIRC and LUSC are the cancer types where WBP1LP1 tumor–normal differential expression is most reproducible.