WBP1L

Across TCGA patient cohorts, WBP1L mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WBP1L-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and eIF4G. Each is linked with WBP1L in more than 1 cancer types. Because this analysis shows association rather than direction, both WBP1L-to-partner and partner-to-WBP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by WBP1L-low versus WBP1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WBP1L→partner) and Y-score (partner→WBP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.665	+1.604	.003	.041	3	2
UCEC	eIF4E →	+0.168	+2.584	.038	.001	3	1
UCEC	eIF4G →	+0.275	+3.321	.021	.009	3	1
UCEC	ACC_pS79 →	+0.339	+2.584	.010	.010	3	1
UCEC	Ku80 →	+0.207	+1.691	.022	.014	3	1
UCEC	Notch1 →	+0.155	+3.598	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Caspase-7-cleavedD198 by WBP1L expression — UCEC

Explore this box plot interactively →