WBP1L

Across TCGA pan-cancer cohorts, WBP1L RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated WBP1L data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher WBP1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WBP1L expression acts as an unfavorable survival marker, although some lineages such as UCS and MESO show a favorable association.

UVM, ACC, and UCS are the cancer types where WBP1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.436	0.752	<.001	95	view →
ACC	DFS	Tertile	All	0.217	0.767	<.001	78	view →
UCS	DFS	Tertile	All	0.602	0.195	.003	76	view →
MESO	OS	Tertile	All	0.752	0.395	<.001	72	view →
KIRC	OS	Median	All	0.722	0.546	<.001	58	view →
BLCA	DFS	Median	All	0.376	0.607	.006	44	view →
LUSC	DFS	Tertile	II,III,IV	0.309	0.536	.001	44	view →
LGG	DFS	Median	All	0.873	0.784	<.001	38	view →
HNSC	DFS	Tertile	All	0.417	0.245	.002	35	view →
ESCA	OS	Median	All	0.635	0.473	.006	32	view →
UCEC	DFS	Quartile	III,IV	0.864	0.652	.003	28	view →
CHOL	DFS	Quartile	II,III,IV	1.000	0.131	.011	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

WBP1L–UVM (DFS)

Open the UVM breakdown →