WBP11

Across TCGA pan-cancer cohorts, WBP11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WBP11 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WBP11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WBP11 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

HNSC, COAD, and PDAC are the cancer types where WBP11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.730	0.971	<.001	52	view →
COAD	DFS	Median	All	1.000	0.887	.020	30	view →
PDAC	DFS	Tertile	All	0.485	0.218	.006	27	view →
LUAD	OS	Tertile	III,IV	0.911	0.325	.011	4	view →
LSCC	OS	Quartile	All	1.000	0.935	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WBP11–HNSC (OS)

Open the HNSC breakdown →