WBP11

Across TCGA pan-cancer cohorts, WBP11 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WBP11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where WBP11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WBP11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where WBP11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WBP11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.696	<.001	9	view →
THCA	All	II,III,IV	−0.571	<.001	9	view →
COAD	All	II,III,IV	+0.450	<.001	9	view →
LIHC	All	II,III,IV	+0.746	<.001	8	view →
STAD	Male	II,III,IV	+0.761	<.001	7	view →
BRCA	All	III,IV	+0.461	<.001	6	view →
CHOL	Female	All	+1.833	<.001	5	view →
LUSC	Male	II,III,IV	+0.696	<.001	5	view →
KIRP	All	II,III,IV	+0.430	.014	4	view →
BLCA	All	All	+0.321	.021	4	view →
ESCA	Female	All	+0.870	.016	2	view →
READ	All	III,IV	+0.355	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WBP11–HNSC

Open the HNSC breakdown →