WBP11

Across TCGA patient cohorts, WBP11 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WBP11-associated genes across cancer lineages are Smac, A-Raf_pS299, and MEK1. Each is linked with WBP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both WBP11-to-partner and partner-to-WBP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by WBP11-low versus WBP11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WBP11→partner) and Y-score (partner→WBP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smac →	+0.316	+2.820	.032	.035	3	2
UCEC	A-Raf_pS299 →	-0.127	-2.000	.002	.009	3	2
UCEC	MEK1 →	+0.305	+1.736	.016	.007	3	2
UCEC	MSH2 →	-0.247	-2.196	.001	.009	3	2
UCEC	Rad50 →	-0.261	-2.308	.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.482	+2.115	.019	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Smac by WBP11 expression — SKCM

Explore this box plot interactively →