WASHC2C

Across TCGA pan-cancer cohorts, WASHC2C mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of WASHC2C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where WASHC2C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types WASHC2C is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, PDAC, and LUAD are the cancer types where WASHC2C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WASHC2C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	−0.382	<.001	8	view →
PDAC	All	All	+0.279	.003	6	view →
LUAD	Male	II,III,IV	−0.162	<.001	5	view →
HNSC	Male	All	−0.145	.005	4	view →
COAD	Male	II,III,IV	−0.172	.008	3	view →
OV	All	All	+0.531	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

WASHC2C–LSCC

Open the LSCC breakdown →