WASHC2C

Across TCGA pan-cancer cohorts, WASHC2C RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated WASHC2C data layer compared with 9 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher WASHC2C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WASHC2C expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

LIHC, KICH, and KIRC are the cancer types where WASHC2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.432	0.625	<.001	76	view →
KICH	OS	Median	II,III,IV	0.609	0.965	.001	74	view →
KIRC	DFS	Median	All	0.746	0.511	<.001	56	view →
SKCM	OS	Median	II,III,IV	0.884	0.791	.001	42	view →
UVM	DFS	Median	III,IV	0.350	0.758	.001	38	view →
LUSC	DFS	Median	III,IV	0.512	0.914	.006	29	view →
LGG	OS	Tertile	All	0.660	0.388	<.001	27	view →
ACC	DFS	Quartile	All	0.231	0.612	.006	24	view →
SCLC	OS	Quartile	All	0.747	0.476	.009	16	view →
LUAD	OS	Median	II,III,IV	0.622	0.501	.020	15	view →
HNSC	DFS	Quartile	IV	0.445	0.224	.002	13	view →
COAD	OS	Tertile	All	0.725	0.876	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

WASHC2C–LIHC (DFS)

Open the LIHC breakdown →