WASHC2C

Across TCGA patient cohorts, WASHC2C mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASHC2C-associated genes across cancer lineages are Di-Ras3, Src, and FoxM1. Each is linked with WASHC2C in more than 2 cancer types. Because this analysis shows association rather than direction, both WASHC2C-to-partner and partner-to-WASHC2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by WASHC2C-low versus WASHC2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASHC2C→partner) and Y-score (partner→WASHC2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.123	-3.156	.003	<.001	3	3
SKCM	Src →	-0.250	-3.459	.029	.005	3	2
UCEC	FoxM1 →	+0.174	+1.347	.019	.006	3	2
UCEC	FOXO3a_pS318_S321 →	-0.084	-1.247	.019	.038	3	2
UCEC	p62 Lck ligand →	+0.302	+1.948	.001	<.001	3	2
UCEC	ATM →	-0.344	-1.489	.008	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Di-Ras3 by WASHC2C expression — UCEC

Explore this box plot interactively →