WASHC1

Across TCGA patient cohorts, WASHC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,141 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible WASHC1-associated GO terms across cancer lineages are Regulation of Arp2/3 complex-mediated actin nucleation, Regulation of actin nucleation, and Obsolete regulation of phosphatidylinositol 3-kinase activity. Each is linked with WASHC1 in more than 29 cancer types. Because this analysis shows association rather than direction, both WASHC1-to-partner and partner-to-WASHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Arp2/3 complex-mediated actin nucleation grouped by WASHC1-low versus WASHC1-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WASHC1→partner) and Y-score (partner→WASHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Regulation of Arp2/3 complex-mediated actin nucleation →	+0.075	+0.891	.001	<.001	2	30
SCLC	Regulation of actin nucleation →	+0.070	+0.725	.002	.008	2	29
SCLC	Obsolete regulation of phosphatidylinositol 3-kinase activity →	+0.113	+1.121	<.001	<.001	3	24
TGCT	tRNA thio-modification →	+0.038	+0.602	<.001	<.001	3	23
ACC	Regulation of telomere maintenance in response to DNA damage →	+0.035	+0.857	<.001	<.001	3	23
KIRP	Base-excision repair, AP site formation →	+0.061	+0.820	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,141 associations by consensus.

Regulation of Arp2/3 complex-mediated actin nucleation by WASHC1 expression — SCLC

Explore this box plot interactively →