WASF3

Across TCGA patient cohorts, WASF3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASF3-associated genes across cancer lineages are Cyclin-B1, Notch1, and PCNA. Each is linked with WASF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both WASF3-to-partner and partner-to-WASF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by WASF3-low versus WASF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASF3→partner) and Y-score (partner→WASF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.397	+3.321	.045	.009	3	3
UCEC	Notch1 →	+0.133	+2.472	.007	.010	3	2
UCEC	PCNA →	+0.182	+2.222	.017	.010	3	2
UCEC	ATM →	-0.336	-1.662	.035	.011	3	2
UCEC	Bak →	+0.219	+1.906	.013	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.825	+2.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Cyclin-B1 by WASF3 expression — UCEC

Explore this box plot interactively →