WASF3

Across TCGA pan-cancer cohorts, WASF3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WASF3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WASF3 RNA is repressed in tumor relative to normal tissue. In most cancer types WASF3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LUAD are the cancer types where WASF3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WASF3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−2.784	<.001	11	view →
KIRC	Male	II,III,IV	−1.905	<.001	11	view →
LUAD	Female	III,IV	−2.307	<.001	9	view →
LUSC	Female	II,III,IV	−2.145	<.001	9	view →
HNSC	All	III,IV	+0.695	.008	7	view →
BRCA	All	III,IV	−2.013	<.001	6	view →
UCEC	All	All	−1.854	<.001	6	view →
KICH	All	All	−1.225	<.001	6	view →
COAD	All	II,III,IV	−0.687	.001	6	view →
KIRP	Male	All	−0.995	<.001	4	view →
BLCA	Male	IV	−1.455	.013	3	view →
READ	Female	All	−2.019	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WASF3–THCA

Open the THCA breakdown →